Potential Oxford vaccine fails to prevent coronavirus spread in monkeys, but protects from pneumonia

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Potential Oxford vaccine fails to prevent coronavirus spread in monkeys, but protects from pneumonia

This vaccine is among the eight that are ahead in terms of being tested in humans for efficacy

A high-profile potential vaccine forCOVID-19 being tested by researchers at Oxord University failed to protect vaccinated monkeys from being infected by the virus. However, the test animals appeared to be protected from pneumonia.
The vaccine candidate, ChAdOx1 nCoV-19, being tested is a weakened form a common cold virus (adenovirus) that affects chimpanzees but has been neutered to prevent replication in humans.
Reports of the candidate vaccine’s performance in monkeys (rhesus macaque) have prompted researchers to test the vaccine’s potency in humans. Its promise has also led to Indian vaccine manufacturer, the Pune-based Serum Institute announcing plans to manufacture a four to five million doses by end-May in India. It is one of seven global institutions that will manufacture the vaccine being developed by the Oxford Vaccine Group.
However, detailed results of the trials in monkeys available on pre-print serverbioRxiv suggest that, based on these results, the vaccine may not be the panacea to protecting people from being infected and passing on the infection to others. The research paper is yet to be peer-reviewed.
Rajesh Gokhle, Faculty, National Institute of Immunology and former head of the CSIR-Insitute of Genomics and Integrative Biology, who has read the paper, said that in an “ideal” world, no company would continue testing the vaccine in humans based on the available data in monkeys.

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